Prof. Graham Walker from MIT explains in this video below the metabolism of glucose in a living cell. He starts off by explaining how glucose molecules gets converted to pyruvate in 10 enzymatic steps, including the production of 2 ATP and 2 NADH (electron currency of a cell), in a process called glycolysis. The Pyruvate then migrates to the mitochondrion to produce acetyl-CoA and eventually to CO2 in a process called citric acid cycle, when oxygen is present in a system. This process happens in an organelle called Mitochondrion in a living cell. The final stage in the break down process is the electron transport chain. This process converts NADH’s to NAD thereby converting ADP to ATP (energy currency of the cell).
Prof. Jens Nielsen, my research advisor in Denmark, is a world expert in the field of metabolic engineering and he has exploited microbes to produce products of interest. In this video he explains the use of fungi as factories.
- You can search through the entire book ‘Molecular Cell Biology’ by Harvey Lodish, Arnold Berk, S Lawrence Zipursky, Paul Matsudaira, David Baltimore, and James Darnell, at Pubmed
- The Science and Applications of Synthetic and Systems Biology
- National Center for Biotechnology Information’s Bookshelf provides free access to books and documents in life science and healthcare